Collagen with Vitamin C and Hyaluronic Acid

Porfírio, Elisângela & Fanaro, Gustavo. (2016). Collagen supplementation as a complementary therapy for the prevention and treatment of osteoporosis and osteoarthritis: a systematic review. Revista Brasileira de Geriatria e Gerontologia. 19. 153-164. DOI: 10.1590/1809-9823.2016.14145

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Can I take hyaluronic acid and collagen together?
Can I take collagen and vitamin C together?
Is hyaluronic acid necessary with collagen?
Is collagen better absorbed with vitamin C?

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Biotin

Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34. PMID: 23198010

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Floersheim G. L. (1989). Behandlung brüchiger Fingernägel mit Biotin [Treatment of brittle fingernails with biotin]. Zeitschrift fur Hautkrankheiten, 64(1), 41–48. PMID: 2648686

Hochman, L. G., Scher, R. K., & Meyerson, M. S. (1993). Brittle nails: response to daily biotin supplementation. Cutis, 51(4), 303–305. PMID: 8477615

Scheinfeld, N., Dahdah, M. J., & Scher, R. (2007). Vitamins and minerals: their role in nail health and disease. Journal of drugs in dermatology : JDD, 6(8), 782–787. PMID: 17763607

Vitamin C

Wu M, Cronin K, Crane JS. Biochemistry, Collagen Synthesis. [Updated 2020 Apr 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.

Boyera, N., Galey, I., & Bernard, B. A. (1998). Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. International journal of cosmetic science, 20(3), 151–158. DOI: 10.1046/j.1467-2494.1998.171747.x

Lis, D. M., & Baar, K. (2019). Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. International journal of sport nutrition and exercise metabolism, 29(5), 526–531. DOI: 10.1123/ijsnem.2018-0385

Kleszczewska E. (2007). Biologiczne znaczenie witaminy C ze szczególnym z uwzglednieniem jej znaczenia w metabolizmie skóry [Biological role and importance in the skin metabolism of vitamin C]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 23(138), 462–465. PMID: 18432133

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Carr, A. C., & Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9(11), 1211. DOI: 10.3390/nu9111211

Ströhle, A., & Hahn, A. (2009). Vitamin C und Immunfunktion [Vitamin C and immune function]. Medizinische Monatsschrift fur Pharmazeuten, 32(2), 49–56. PMID: 19263912

Vitamin E

Vardi M, Levy NS, Levy AP. Vitamin E in the prevention of cardiovascular disease: the importance of proper patient selection. J Lipid Res. 2013;54(9):2307‐2314. doi: 10.1194/jlr.R026641

Saremi, A., & Arora, R. (2010). Vitamin E and cardiovascular disease. American journal of therapeutics, 17(3), e56–e65. DOI: 10.1097/MJT.0b013e31819cdc9a

Lewis, E. D., Meydani, S. N., & Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB life, 71(4), 487–494. DOI: 10.1002/iub.1976

Institute of Medicine (US) Committee on Military Nutrition Research. Military Strategies for Sustainment of Nutrition and Immune Function in the Field. Washington (DC): National Academies Press (US); 1999. 13, Vitamin E, Vitamin C, and Immune Response: Recent Advances.

Moriguchi, S., & Muraga, M. (2000). Vitamin E and immunity. Vitamins and hormones, 59, 305–336. DOI: 10.1016/s0083-6729(00)59011-6

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Moriguchi, S., Hamada, M., Yamauchi, K., Sakai, K., & Yamamoto, S. (1998). The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. The journal of medical investigation : JMI, 45(1-4), 1–8. PMID: 9864960

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Hyaluronic Acid

Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253‐258. doi: 10.4161/derm.21923

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Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):27‐29. PMID: 24688623

Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front Vet Sci. 2019;6:192. Published 2019 Jun 25. doi: 10.3389/fvets.2019.00192

Kawada C, Yoshida T, Yoshida H, et al. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014;13:70. Published 2014 Jul 11. doi: 10.1186/1475-2891-13-70

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Tashiro T, Seino S, Sato T, Matsuoka R, Masuda Y, Fukui N. Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. ScientificWorldJournal. 2012;2012:167928. doi: 10.1100/2012/167928

Altman, R., Hackel, J., Niazi, F., Shaw, P., & Nicholls, M. (2018). Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: A systematic review. Seminars in arthritis and rheumatism, 48(2), 168–175. DOI: 10.1016/j.semarthrit.2018.01.009

Concoff, A., Sancheti, P., Niazi, F., Shaw, P., & Rosen, J. (2017). The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC musculoskeletal disorders, 18(1), 542. DOI: 10.1186/s12891-017-1897-2

Altman, R. D., Bedi, A., Karlsson, J., Sancheti, P., & Schemitsch, E. (2016). Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. The American journal of sports medicine, 44(8), 2158–2165. DOI: 10.1177/0363546515609599

Witteveen, A. G., Hofstad, C. J., & Kerkhoffs, G. M. (2015). Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle. The Cochrane database of systematic reviews, (10), CD010643. DOI: 10.1002/14651858.CD010643.pub2

Maheu, E., Rannou, F., & Reginster, J. Y. (2016). Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Seminars in arthritis and rheumatism, 45(4 Suppl), S28–S33. DOI: 10.1016/j.semarthrit.2015.11.008

Can I take hyaluronic acid and collagen together?

Collagen and hyaluronic acid go together like best friends. When taken together as a supplement, they complement and support one another for maximal, effective benefits. HA enhances the body's ability to produce and synthesize collagen – or in other words, hyaluronic acid helps the body “use” collagen.

Can I take collagen and vitamin C together?

Yes, you can take collagen and vitamin C together. In fact, doing so will likely boost your skin health even more than if you just took one of the supplements on its own.

Is hyaluronic acid necessary with collagen?

Taking both is ideal if you are looking for a top notch anti-aging supplement plan. Hyaluronic acid is an essential component of the skin because of its ability to promote collagen. Collagen firms the skin while hyaluronic acid nourishes and hydrates the collagen.

Is collagen better absorbed with vitamin C?

Vitamins (like C) added into a collagen product does not actually improve collagen absorption or help maximize your collagen-making cells to make more healthy collagen. In fact, it may trigger harmful oxidation of certain amino acids in the collagen supplement during storage that would reduce the supplement's efficacy.