Feed pepino

. 2016 Jan 15;96(1):192-8.

doi: 10.1002/jsfa.7081. Epub 2015 Feb 27.


  • PMID: 25582456
  • DOI: 10.1002/jsfa.7081

In vitro anti-inflammatory properties of fermented pepino (Solanum muricatum) milk by γ-aminobutyric acid-producing Lactobacillus brevis and an in vivo animal model for evaluating its effects on hypertension

Vincent Hung-Shu Chang et al. J Sci Food Agric. 2016.


Background: The objectives of this study were to determine the in vitro anti-inflammatory and in vivo antihypertensive effects of fermented pepino (Solanum muricatum) milk by Lactobacillus brevis with the goal of developing functional healthy products. The inflammatory factors of fermented pepino milk with L. brevis were assessed in RAW 264.7 macrophages, including nitric oxide (NO) production. Inflammatory factor genes of cyclooxygenase (COX)-1 and -2, and tumor necrosis factor (TNF)-α were also assayed by a reverse transcription-polymerase chain reaction (RT-PCR).

Results: Results showed that fermented PE inhibited NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with 150 mg mL(-1) fermented PE completely blocking LPS-induced NO production. The mRNA expressions of COX-1, COX-2, and iNOS were attenuated by treatment with higher concentrations of fermented PE (150 mg/ml). Cells treated with fermented pepino extract (PE) (100 ng mL(-1)) exhibited strikingly decreased LPS-induced expression of TNF-α mRNA. During the feeding trial, rats treated with 10% fermented pepino milk (100 µg 2.5 mL(-1)) and 100% fermented pepino milk (1000 µg 2.5 mL(-1)) exhibited significant decreases in the systolic blood pressure.

Conclusion: Our results showed that fermented pepino milk has wide potential applications for development as a health food.

Keywords: Lactobacillus brevis; anti-inflammation; antihypertensive; pepino; γ-aminobutyric acid.

© 2015 Society of Chemical Industry.

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How do you take care of a pepino plant?

Pepino plants may be grown in sandy, loamy, or even heavy clay soils, although they prefer alkaline, well-draining soil with an acid neutral pH. Pepinos should be planted in sun exposure and in moist soil. Sow the pepino seeds in the early spring indoors or in a warm greenhouse.

How often should I water pepino?

6. Water the pepino when the top inch of soil feels dry. In hot weather, pepinos may require once or twice daily watering. Pour the water directly onto the soil at the base of the plant until the excess drains from the bottom of the pot.

Does pepino need full sun?

Ideal Growing Condition For Pepino Melon Pepino plants are ideally grown in a temperate climate. They prefer a neutral pH soil level, as do many fruits and vegetables. The bush prefers a full-sun to part-shade position in the garden.

Are pepinos self pollinating?

Pepino dulce is parthenocarpic, meaning it does not need pollination to set fruit. However, it produces a heavier crop if other pepinos are nearby to cross-pollinate. It will not set fruit until evening temperatures reach 65 degrees.