What are the 4 types of teratogens?

Medical Genetics: Teratogens

What is a teratogen?

A teratogen (ter-AT-uh-jen) is something that can cause or raise the risk for a birth defect in a baby. They are things that a mother may be exposed to during her pregnancy. Teratogens include:

  • Some medicines

  • Street drugs

  • Alcohol

  • Tobacco

  • Toxic chemicals

  • Some viruses and bacteria

  • Certain health conditions, such as uncontrolled diabetes

The riskiest times of pregnancy

Experts believe that teratogens can begin affecting a baby growing in the womb about 10 to14 days after conception. Conception is when a woman’s egg is fertilized by a man’s sperm. After conception, it takes about 6 to 9 days for the egg to implant in the uterus. Once the fertilized egg is attached to the uterus, the mother and the embryo share a blood supply. Chemicals in the mother's blood can then affect the growing baby.

As a baby grows in the womb, teratogens may affect parts of the baby’s body as they are forming. For example, the neural tube closes in the first 3 to 5 weeks of the pregnancy. During this time, teratogens can cause neural tube defects such as spina bifida. Some organs are sensitive to teratogens during the whole pregnancy. This includes the baby's brain and spinal cord. Alcohol affects the brain and spinal cord, so it can cause harm at any time during pregnancy. This is why you should not drink alcohol if you are pregnant.

How are teratogens known?

Researchers have two ways of finding out if a substance is a teratogen. They are:

  • Animal studies. Animal studies are the main way to find out if a medicine or other substance is safe during human pregnancy.

  • Observations from human exposure. This means reports of problems about a substance over time .

What are nonteratogenic agents?

Certain things have been shown to not cause birth defects. These are called nonteratogenic agents. These include:

  • Spermicides. These are chemicals that kill sperm to prevent pregnancy. These chemicals are found in products for birth control, such as gels, creams, and foams, and on some condoms. Studies have shown no link with the use of spermicides and any increased chance for birth defects.

  • Acetaminophen. This is a common ingredient in some pain medicines. There has been no link between birth defects and taking acetaminophen at the advised dose during pregnancy.

  • Prenatal vitamins. Prenatal vitamins are prescribed to pregnant women to help meet the extra nutritional needs of pregnancy. When used at the recommended dose, they don’t increase the risk for birth defects. But don’t take any extra vitamins, minerals, or herbal supplements without talking with your healthcare provider first. Extra amounts may be harmful.

  • Microwave ovens. Microwave ovens use nonionizing radiation. This type of radiation is not teratogenic. Microwaving food while pregnant is not known to increase the risk for birth defects or health problems.

Talking with your healthcare provider  

If you’re pregnant, talk with your healthcare provider about things to avoid during pregnancy that may cause birth defects. He or she can help answer your questions and help you have a safe pregnancy.

What is a teratogen?

A teratogen is an agent, which can cause a birth defect. It is usually something in the environment that the mother may be exposed to during her pregnancy. It could be a prescribed medication, a street drug, alcohol use, or a disease present in the mother which could increase the chance for the baby to be born with a birth defect. About 4 to 5 percent of birth defects are caused by exposure to a teratogen.

What are the most sensitive periods for teratogens in pregnancy?

Once the egg is fertilized (conception), it takes about six to nine days for implantation (anchoring into the uterus) to occur. Once the fertilized egg is connected to the uterus, a common blood supply exists between the mother and the embryo. In other words, if something is in the mother's blood, it can now cross over to the developing fetus. Teratogens are thought to have the ability to effect the fetus about 10 to14 days after conception.

During the development of a baby, there are certain organs forming at certain times. If a teratogen has the potential to interfere with the closure of the neural tube, for example, the exposure to the teratogen must occur in the first 3.5 to 4.5 weeks of the pregnancy, since this is when the neural tube is closing. There are some organ systems that are sensitive to teratogens throughout the entire pregnancy, such as the central nervous system. The central nervous system is the baby's brain and spine. One teratogen that affects the central nervous system is alcohol. Alcohol, at any time during the pregnancy, has the potential to cause birth defects and health problems in the baby, since the central nervous system is sensitive to teratogens the entire nine months of gestation. This is why alcohol consumption should be avoided in its entirety during pregnancy.

There are many different teratogens that cause birth defects. Listed in the directory below are some, for which we have provided a brief overview.

  • Alcohol 
  • Phenytoin (Dilantin) 
  • Varicella
  • Examples of Non-Teratogenic Agents: Spermicides, Acetaminophen, Prenatal Vitamins, Using a Microwave to Cook Food
  • Identifying Teratogens

What are the three most common teratogens?

Common teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, uncontrolled health problems in the birthing parent. Alcohol is a well-known teratogen that can cause harmful effects on the fetus after exposure at any time during pregnancy.

What are 5 types of teratogens?

Known Teratogens.
angiotensin converting enzyme (ACE) inhibitors, such as Zestril and Prinivil..
alcohol..
aminopterin..
androgens, such as methyltestosterone (Android).
busulfan (Myleran).
carbamazepine (Tegretol).
chlorobiphenyls..
cocaine..

What are teratogens give examples?

A teratogen is a substance that may lead to birth defects in an embryo or fetus. During pregnancy, exposure to certain chemicals, infections, and drugs may increase the risk that a person will miscarry or that the embryo or fetus could have a developmental abnormality. Alcohol and smoking are two common teratogens.

What is one of the most commonly used teratogens?

One of the most commonly used teratogens is alcohol and because half of all pregnancies in the United States are unplanned, it is recommended that women of child-bearing age take great caution against drinking alcohol when not using birth control or when pregnant (Surgeon General's Advisory on Alcohol Use During ...