Which drug may prevent or limit ventricular remodeling

Which statement made by the student nurse indicates effective learning about cardiovascular disease?

a. "Nicotine stimulates catecholamine release."

b. "Isometric exercise provides relief from angina."

c. "Manifestations of angina often occur in the late evenings."

d. "Decreased heart rate increases myocardial oxygen demand."

a. "Nicotine stimulates catecholamine release."

Rationale
Chronic stable angina occurs due to insufficient blood flow in the coronary arteries due to atherosclerosis. Nicotine is a precipitating factor that provokes the angina attack because nicotine use stimulates catecholamine release, causing vasoconstriction and increased heart rate. Isometric exercise, such as lifting heavy objects, promotes the onset of angina; the patient should take nitroglycerin 5 to 10 minutes before beginning activities that are known to cause angina. Manifestations of angina occur in the early mornings due to a change in the circadian rhythm patterns. Increased heart rate due to exertion reduces the time the heart spends in diastole, resulting in increased myocardial oxygen demand.

Which drug breaks up the fibrin meshwork in clots?

A. Nadolol

B. Alteplase

C. Valsartan

D. Nicardipine

B. Alteplase

Rationale
Alteplase is a thrombolytic agent that breaks up the fibrin meshwork in clots. Nadolol is a β-adrenergic blocker that inhibits sympathetic nervous stimulation of the heart. Valsartan is an angiotensin II receptor blocker, which inhibits the binding of angiotensin II to angiotensin I receptors. Nicardipine is a calcium channel blocker that prevents calcium entry into the vascular smooth muscles and cardiac cells.

Which drug produces an anticoagulant effect by interfering with hepatic synthesis of vitamin K-dependent clotting factors?

A. Warfarin

B. Prasugrel

C. Argatroban

D. Eptifibatide

A. Warfarin

Rationale
Warfarin interferes with hepatic synthesis of the vitamin K-dependent clotting factors that result in an anticoagulant effect. Prasugrel causes an antiplatelet effect by inhibiting platelet aggregation. Argatroban acts by directly inhibiting the clotting factor thrombin and results in an anticoagulant effect. Eptifibatide prevents the binding of fibrinogen to platelets, thereby blocking platelet aggregation.

p. 715

Which statement by a patient diagnosed with stable angina indicates understanding of the disease process?

A. "Angina is caused by spasms within a coronary blood vessel."

B. "Angina is causing an irreversible damage to my cardiac muscles by cardiac ischemia."

C. "Anginal pain is caused by an increased demand for oxygen or a decreased supply of oxygen."

D. "Symptoms of angina start when the process of atherosclerosis completely occludes a coronary artery."

C. "Anginal pain is caused by an increased demand for oxygen or a decreased supply of oxygen."

Rationale
A mismatch between oxygen demand of cardiac muscles and supply of oxygen leads to myocardial ischemia, which is manifested as pain. Prinzmetal's angina is caused by coronary vasospasm. Myocardial ischemia is completely reversible. The patient will start to experience symptoms of ischemia when the coronary artery is blocked by 75% or more.
P. 712

A patient with angina takes a total of three nitroglycerin tablets, five minutes apart. The patient's chest pain is not relieved. What is the nurse's priority action?

A. Assess vital signs.

B. Repeat the medication in five minutes.

C. Contact the emergency medical services (EMS).

D. Instruct the patient to lie quietly and to take deep breaths.

C. Contact the emergency medical services (EMS).

Rationale
A patient with angina who takes sublingual nitroglycerin and whose condition worsens or does not resolve after administration of the medication should be referred to an emergency medical service (EMS) immediately for help. The drug should be administered to the patient every five minutes for a maximum of three doses. The nurse should take measures to reduce the severity of the condition first and then monitor vital signs or to provide patient instructions.

Which drug causes vasodilation by preventing conversion of angiotensin I to angiotensin II?

A. Enalapril

B. Losartan

C. Amlodipine

D. Nitroglycerin

A. Enalapril

Rationale
Enalapril is an angiotensin-converting enzyme (ACE) inhibitor that inhibits the conversion of angiotensin I to angiotensin II, resulting in vasodilation. Losartan is an angiotensin II receptor blocker that inhibits the binding of angiotensin II to angiotensin I receptors. Amlodipine is a calcium channel blocker that prevents calcium entry into the vascular smooth muscles and myocytes. Nitroglycerin is short-acting nitrate that causes peripheral vasodilation, thereby decreasing preload and afterload.

p. 715

The nurse is performing an assessment on a newly admitted patient who presented to the emergency department with reports of chest pain. Which assessment data would indicate that the patient has stable angina?

A. The patient developed chest pain shortly after going to bed.

B. The patient developed chest pain while sitting and reading a book.

C. The pain developed when the patient was jogging and subsided after the patient rested.

D. The pain starts approximately the same time every day without regard to activity level.

C. The pain developed when the patient was jogging and subsided after the patient rested.

Rationale
Pain associated with stable angina is precipitated by increased demand of myocardial muscle for oxygen that happens with exercising or other activity and subsides with rest in 5 to 15 minutes. Prinzmetal's angina (variant angina) occurs at rest. Nocturnal angina occurs when patient is supine in bed. Prinzmetal's angina (variant angina) is characterized by pain that occurs at the same time of the day.

A patient with stable angina takes a short-acting nitrate. The nurse recognizes that it is important to monitor the patient for what?

A. Decrease in heart rate

B. Decreased ejection fraction

C. Decrease in blood pressure

D. Prolonging of the QT interval

C. Decrease in blood pressure

Rationale
The patient has symptoms of unstable angina. The patient on short-acting nitrates such as nitroglycerin may experience orthostatic hypotension, so the blood pressure of the patient should be monitored regularly and the patient asked to make slow movements. A patient on fluoxetine must undergo monitoring for QT interval prolongation because this medication prolongs the QT interval. The patient on beta-adrenergic blockers may experience bradycardia and should be monitored for a decrease in the heart rate. The patients with heart failure should be monitored for ejection fraction.

p. 716

Which drug may prevent or limit ventricular remodeling?
A. Captopril

B. Valsartan

C. Metoprolol

D. Nitroglycerin

A. Captopril

Rationale
Captopril is an angiotensin-converting enzyme (ACE) inhibitor that may prevent or limit ventricular remodeling. Valsartan is an angiotensin II receptor blocker that is used in patients who are intolerant to angiotensin-converting enzyme (ACE) inhibitor. Metoprolol is a β-adrenergic blocker that reduces heart rate, contractility, and blood pressure. Nitroglycerin is a nitrate that promotes coronary artery vasodilation.

Which drugs act by decreasing the contractility of the heart? Select all that apply.

A. Captopril

B. Diltiazem

C. Valsartan

D. Carvedilol

E. Morphine

B. Diltiazem
D. Carvedilol

Rationale
Diltiazem is a calcium channel blocker that reduces the heart rate, contractility, and blood pressure. Carvedilol is a β-adrenergic blocker that also reduces the heart rate, contractility, and blood pressure. Captopril is an angiotensin-converting enzyme (ACE) inhibitor that causes vasodilation by preventing conversion of angiotensin I to angiotensin II. Valsartan is an angiotensin II receptor blocker that causes vasodilation by inhibiting the binding of angiotensin II to angiotensin I receptors. Morphine is an opioid analgesic that acts as a vasodilator and reduces preload and myocardial oxygen consumption.

The nurse is caring for a female patient that reports chest pain while performing daily activities. The patient's chest x-ray reveals that there is no significant coronary atherosclerosis. Which condition is indicated in the patient?

A. Silent ischemia

B. Nocturnal angina

C. Angina decubitus

D. Microvascular angina

D. Microvascular angina

Rationale
The patient may have microvascular angina, which is chest pain that occurs in the absence of significant coronary atherosclerosis or coronary spasm; it is especially common in women. The chest pain is related to myocardial ischemia associated with abnormalities of coronary microcirculation. If the ischemia occurs in the absence of any subjective symptoms, then the condition is silent ischemia. Nocturnal angina occurs only at night. Angina decubitus occurs only when the patient is lying down or is in a recumbent position, and is relieved when the patient is in the sitting or standing position.

Which drugs act by causing vasodilation either directly or indirectly? Select all that apply.
A. Losartan

B. Morphine

C. Reteplase

D. Carvedilol

E. Bivalirudin

A. Losartan B. Morphine

Rationale
Losartan is an angiotensin II receptor blocker that inhibits binding of angiotensin II to angiotensin I receptors, thereby causing vasodilation. Morphine is an opioid analgesic that acts as a vasodilator to reduce preload and myocardial oxygen consumption. Reteplase is a thrombolytic agent that breaks up the fibrin meshwork in clots. Carvedilol is a β-adrenergic that reduces the heart rate, contractility, and blood pressure. Bivalirudin is a direct thrombin inhibitor that directly inhibits the clotting factor thrombin.

pp. 715-716

Which drug prevents the binding of fibrinogen to platelets, thereby preventing platelet aggregation?

A. Heparin

B. Tirofiban

C. Ticagrelor

D. Dalteparin

B. Tirofiban

Rationale
Tirofiban is a glycoprotein IIb/IIIa inhibitor, which prevents the binding of fibrinogen to platelets, thereby blocking platelet aggregation. Heparin is an anticoagulant, which prevents conversion of fibrinogen to fibrin and prothrombin to thrombin. Ticagrelor is an antiplatelet agent, which inhibits platelet aggregation. Dalteparin is a low-molecular-weight heparin, which binds to antithrombin III, enhancing its effect.

p. 715

A patient that smokes reports chest pain while at rest. The nurse suspects that the patient is experiencing which condition?

a. Silent ischemia

b. Angina decubitus

c. Prinzmetal's angina

d. Chronic stable angina

c. Prinzmetal's angina
Rationale
Prinzmetal's angina often occurs at rest, usually in response to spasms of a major coronary artery due to nicotine, which cause the release of catecholamines such as epinephrine and norepinephrine. When the spasms occur, the patient experiences pain and ST segment elevation. Silent ischemia refers to the ischemia that occurs in the absence of any subjective symptoms. Angina decubitus is chest pain that occurs only when the patient is lying down. Chronic stable angina does not occur at rest and is triggered by physical exertion.
p. 713

Which drugs may be prescribed for patients with chronic stable angina to help optimize myocardial perfusion? Select all that apply.

a. Aspirin
b. Atenolol
c. Captopril
d. Atorvastatin
e. Nitroglycerin

b. Atenolol
c. Captopril
e. Nitroglycerin

Rationale
Angiotensin-converting enzyme inhibitors such as captopril, β-adrenergic blockers such as atenolol, and nitrates such as nitroglycerin are used to optimize myocardial perfusion. Aspirin is an antiplatelet drug, and atorvastatin is a lipid-lowering drug. These drugs are used in patients with angina for managing coronary artery disease.

pp. 715-717

What medication education should the nurse provide to a patient that receives a prescription for isosorbide mononitrate? Select all that apply.
a. "Tolerance to this long-acting nitroglycerin can develop."
b. "Have your blood pressure measured after the initial dose."
c. "Take the medication only when symptoms of angina appear."
d. "Discontinue the medication if a headache occurs after taking the medication."
e. "You may take acetaminophen along with the medication, to relieve headaches."

a. "Tolerance to this long-acting nitroglycerin can develop."
b. "Have your blood pressure measured after the initial dose."
e. "You may take acetaminophen along with the medication, to relieve headaches."

Rationale
The patient should be advised to take acetaminophen along with isosorbide mononitrate to avoid a headache due to the dilation of cerebral blood vessels. The patient should have blood pressure measured after the initial dose because isosorbide mononitrate causes venous dilation that may lead to a drop in blood pressure. Tolerance to the medication may develop; thus patients are scheduled for a 10 to 14-hour nitrate-free period. The patient should not be advised to discontinue the medication if headaches develop. Isosorbide mononitrate is a long-acting nitrate used to reduce the incidence of anginal attacks and should be taken regularly, not only when angina symptoms are present.

The nurse provides care to a patient that undergoes intracoronary stent placement along with balloon angioplasty. Which drugs are used during the procedure to prevent platelet aggregation within the stent? Select all that apply.

a. Verapamil
b. Bivalirudin
c. Eptifibatide
d. Morphine sulfate
e. Isosorbide dinitrate

b. Bivalirudin
c. Eptifibatide

Rationale
A balloon angioplasty is performed in a patient with angina to dilate the coronary blood vessels. A stent is placed to keep the vessel open after the angioplasty. Drugs commonly used during the procedure are unfractionated heparin (UH) or low-molecular weight heparin (LMWH), a direct thrombin inhibitor (e.g., bivalirudin), and/or a glyocoprotein IIb/IIIa inhibitor (e.g., eptifibatide). Verapamil is a calcium channel blocker that is given to a patient with beta blocker intolerance. Morphine sulfate is an analgesic and promotes vasodilation, reducing preload and myocardial oxygen consumption. Isosorbide dinitrate is the first line drug for treatment of angina.

p. 717

Which drug is given along with aspirin to patients with unstable angina and NSTEMI?
a. Heparin
b. Warfarin
c. Clopidogrel
d. Atenolol

a. Heparin

Rationale
For patients with UA and NSTEMI, aspirin and heparin (UH or LMWH) are recommended. Unfractionated heparin prevents conversion of fibrinogen to fibrin and prothrombin to thrombin. LMWH binds to antithrombin III, enhancing its effect. It also prevents conversion of fibrinogen to fibrin. Warfarin is used as an alternative for patients who cannot use aspirin or clopidogrel. Atenolol is a beta-adrenergic blocker which may prevent or control coronary vasospasm.

p. 722

A patient reports episodic chest pain lasting 10 minutes that is provoked by exertion and relieved upon resting. The nurse suspects that the cause of the patient's symptoms is what?

a. Spasm of a major coronary artery
b. Exposure of the thrombogenic surface to plaque
c. Myocardial ischemia due to coronary artery disease
d. Myocardial ischemia secondary to microvascular disease

c. Myocardial ischemia due to coronary artery disease

Rationale
Pain is provoked upon exertion and relieved upon rest due to an increase in demand for oxygen or a decrease in the supply of oxygen that leads to myocardial ischemia secondary to coronary artery disease. Coronary vasospasm leads to Prinzmetal's angina, which primarily occurs at rest. Unstable angina occurs due to the rupture of thickened plaque, exposing thrombogenic surfaces in blood vessels. Microvascular angina is common in women and results from myocardial ischemia secondary to microvascular disease.

p. 712

A patient states, "I have episodes of sharp and stabbing chest pain that last 10 minutes and that occur primarily when I am restocking shelves while at work." The patient is diagnosed with chronic stable angina. Which instruction should the nurse give to the patient to prevent anginal pain while at work?

a. "Perform 30 minutes of moderate exercise before going to work."
b. "Take nitroglycerin 5 to 10 minutes before restocking the shelves."
c. "Take nitroglycerin every 5 minutes throughout the task until the work is complete."
d. "Take a dose of the medication 30 minutes after restocking the shelves to maintain vasodilation."

b. "Take nitroglycerin 5 to 10 minutes before restocking the shelves."

Rationale
Reports of ten minutes of a sharp, stabbing pain when performing strenuous work indicate that the patient is experiencing an attack of chronic stable angina. The patient should be advised to take nitroglycerin prophylactically, 5 to 10 minutes before engaging in the activity. Patients with Prinzmetal's angina may get relief from chest pain by performing moderate exercise. The maximum number of nitroglycerin (NTG) tablets the patient can take is three. Taking the medication after the activity will not prevent the pain.

Which statement made by the student nurse indicates effective learning about microvascular angina?

a. "Pain may occur during rapid eye movement (REM) sleep."

b. "Pain occurs at night and is triggered by the patient lying down."

c. "This type of angina is more common in patients with diabetic neuropathy."

d. "This type of angina is more common in women and is triggered by activities of daily living."

d. "This type of angina is more common in women and is triggered by activities of daily living."

Rationale
Microvascular angina is a chest pain associated with abnormalities of the coronary microcirculation, occurring especially in postmenopausal women. Often the angina is prolonged and brought on by physical exertion. Silent ischemia occurs in the patient with diabetic neuropathy due to the damage of nerves of the cardiovascular system. Nocturnal angina sets in when the patient lies down and is relieved upon standing or sitting. With Prinzmetal's angina, pain may occur during rapid eye movement (REM) sleep.

p. 713

A patient with coronary artery disease (CAD) is being seen in an outpatient health care setting for a routine examination. The patient states, "Over the past few months, I have needed increased amounts of insulin to control my type 1 diabetes mellitus." What is an appropriate goal for the nurse to place on the patient's plan of care, aimed at preventing the progression of CAD?

a. Maintain a Hb A1C level of less than 7%

b. Maintain a body mass index (BMI) between 31-35 kg/m 2

c. Maintain a fasting triglyceride level of less than 175 mg/dL

d. Maintain a serum cholesterol level of less than 250 mg/dL(at least 5 days a week)

a. Maintain a Hb A1C level of less than 7%

Rationale
Managing diabetes reduces the risk of CAD; it includes lifestyle changes and drug therapy to achieve a Hb A1C level of less than 7%. The risk of CAD is associated with a serum cholesterol levels greater than 200 mg/dL or a fasting triglyceride level greater than 150 mg/dL. Obesity is defined as a BMI of greater than 30 mg/m 2.

A female patient reports that she often experiences chest pain while sitting at her desk at work. The nurse suspects what condition?

a. Angina decubitus
b. Diabetic neuropathy
c. Raynaud's phenomenon
d. Coronary microvascular disease

d. Coronary microvascular disease

Rationale
Microvascular angina occurs due to myocardial ischemia, which is associated with abnormalities of the coronary circulation and can also be triggered by daily activities. It is more common in women. The patient with angina decubitus experiences chest pain while lying down which is usually relieved by standing or sitting. Diabetic neuropathy leads to damage of the nerves of the coronary system leading to silent ischemia. The patient with a history of Raynaud's phenomenon may experience Prinzmetal's angina.

p. 713

Which statement made by the student nurse indicates effective learning about Prinzmetal's angina?

a. "The pain may be relieved by moderate exercise."
b. "The patient needs to sleep in recumbent position at night."
c. "The pain is triggered while performing activities of daily living."
d. "The patient should take amphetamines with nitrates during an attack."

a. "The pain may be relieved by moderate exercise."

Rationale
Prinzmetal's angina occurs due to spasms in the coronary artery even when the patient is at rest. The patient may experience cyclic and short bursts of pain that are relieved upon moderate exercise of the arms. Nocturnal angina occurs when the patient is in recumbent position. The patient should not use nitrates and amphetamines together during an attack. Microvascular angina occurs even while performing daily activities due to abnormalities of the coronary microcirculation.

p. 713

A patient with stable angina receives a prescription for isosorbide dinitrate. What medication education should the nurse provide to the patient? Select all that apply.
a. "Change positions slowly after taking this medication."
b. "This is a short-acting nitrate that may produce a headache."
c. "You cannot take sublingual nitroglycerin while taking this medication."
d. "You will be scheduled for a 10- to 14-hour nitrate-free period every day."
e. "You should take this medication as needed when experiencing chest pain."

a. "Change positions slowly after taking this medication."
d. "You will be scheduled for a 10- to 14-hour nitrate-free period every day."

Rationale
The patient receiving nitrates is often scheduled for a 10- to 14-hour nitrate-free period every day to limit tolerance to the long-acting nitroglycerin (NTG). Orthostatic hypotension is caused by venous dilation, and patients should be provided with instructions about safety precautions while taking the medication. Remind patients that taking a long-acting NTG preparation should not keep them from using a translingual or sublingual (SL) NTG if angina develops. The medication is a long-acting nitrate that is taken regularly. The short-acting nitrates are taken as needed. The nurse should warn the patient that headache is a side effect but should not tell the patient that the medication is a short-acting nitrate.

p. 716

A patient reports cyclic and short bursts of pain in the chest during the day and night that are relieved after performing mild exercise. The nurse anticipates a prescription for which medication?

a. Prasugrel

b. Sirolimus

c. Abciximab

d. Verapamil

d. Verapamil

Rationale
Cyclic and short bursts of pain in the chest during the day and night indicate Prinzmetal's angina. Calcium channel blockers such as verapamil and nitrates are useful to control this angina. Prasugrel is an antiplatelet agent used in the treatment of unstable angina. Abciximab is a glycoprotein IIb/IIIa inhibitor that helps prevent the binding of fibrinogen to platelets, thereby blocking platelet aggregation. Sirolimus is used in drug-eluting stents to prevent stent restenosis by preventing the overgrowth of new intima.

pp. 713, 715

A patient that takes amphetamines reports cyclic, short bursts of pain in the chest during the day and late at night. What should the nurse include in the patient's plan of care?
a. Lying in a recumbent position during the attack

b. Performing moderate exercise during the attack

c. Taking 181 to 325 mg of (chewable) aspirin during the attack

d. Standing near a cool environment (such as an open refrigerator) during the attack

b. Performing moderate exercise during the attack

Rationale
A patient with cyclic, short bursts of pain in the chest during the day and at late night may have Prinzmetal's angina. The pain may be relieved with mild to moderate exercise. Exposure to cold temperatures may produce the pain associated with this type of angina. Taking chewable aspirin is recommended for a patient experiencing acute coronary syndrome. Chest pain does not subside upon resting in a recumbent position due to an increased spasm of smooth muscles in the coronary artery.

p. 713

A patient with chronic stable angina is experiencing a prolonged QT interval on the electrocardiogram (ECG) monitor. The nurse reviews the list of drugs prescribed for the patient and should question which medication?

a. Aspirin

b. Heparin

c. Captopril

d. Ranolazine

d. Ranolazine

Rationale
Ranolazine is a sodium current inhibitor that further prolongs the QT interval in patients who have QT prolongation. Aspirin and heparin are safe in patients with chronic stable angina and are used to inhibit clot formation in blood vessels. Captopril is an angiotensin II converting inhibitor that reduces the risk of cardiac events by dilating the blood vessels and reducing blood pressure.

A patient with a history of diabetes is diagnosed with chronic stable angina. The nurse recalls that which drug that decreases endothelial dysfunction would be beneficial to this patient?

a. Diltiazem

b. Sirolimus

c. Captopril

d. Bivalirudin

c. Captopril

Rationale
A patient with a history of diabetes who has chronic stable angina has a high risk for a cardiac event. An angiotensin-converting enzyme (ACE) inhibitor, such as captopril, can be safely used in this patient; it decreases endothelial dysfunction and prevents conversion of angiotensin I to angiotensin II, resulting in vasodilation. Beta blockers such as diltiazem mask the signs of hypoglycemia and are used cautiously in patients with diabetes. Sirolimus is used in drug-eluting stents that prevent the overgrowth of new intima, the primary cause of stent restenosis. Bivalirudin helps prevent the abrupt closure of the stents during percutaneous coronary intervention.

p. 715

Which other assessment finding would the nurse expect in a patient that reports substernal pain radiating to the neck and jaw that occurs when exercising and that lasts for a few minutes?

a. Decrease in the heart rate

b. Depression of the ST segment

c. Persistent pain even when resting

d. Frequent episodes of migraine headache

b. Depression of the ST segment

Rationale
Stable angina pain relates to substernal pain lasting 5 to 15 minutes radiating to the neck and jaw. The 12-lead electrocardiogram (ECG) in a patient with angina has a depression in the ST segment and may also have T wave inversion. The patient with physical exertion has an increased heart rate, which reduces the time the heart spends in diastole, resulting in an increase in myocardial oxygen demand. The pain due to stable angina is usually relieved when the exercise stops. Migraine headache is seen patients taking nitroglycerin due to dilation of the cerebral blood vessels.

The nurse provides information to a patient with Prinzmetal's angina related to risk factors related to this type of angina. What should the nurse include?

a. Diabetes

b. Smoking

c. Postmenopausal state

d. High cholesterol level

b. Smoking

Rationale
Prinzmetal's angina occurs at rest due to coronary artery spasm. It is usually due to spasm of a major coronary artery. Factors contributing to coronary artery spasm include increased myocardial oxygen demand and increased levels of certain substances such as tobacco smoke, alcohol, and cocaine. Patients with diabetes have an increased prevalence of silent ischemia. Microvascular angina is more common in postmenopausal women. High cholesterol is not a risk factor for Prinzmetal's angina.

p. 713

Drug-eluting stents (DES) are coated with which drugs? Select all that apply.

a. Losartan

b. Paclitaxel

c. Captopril

d. Everolimus

e. Ranolazine

b. Paclitaxel
d. Everolimus

Rationale
Drug-eluting stents (DES) are coated with paclitaxel or everolimus. Losartan is an angiotensin II receptor blocker used in patients who are intolerant of angiotensin-converting enzyme (ACE) inhibitors. Captopril is an angiotensin-converting enzyme inhibitor used to treat high risk chronic stable angina. Ranolazine is a sodium current inhibitor, used to treat chronic angina refractory to other medications.

p. 718

A patient with a history of asthma presents to the emergency department with wheezing, chest pain, and shortness of breath. The nurse reviews the patient's medication profile and identifies that which type of medication may be responsible for the patient's symptoms?

a. Short-acting nitrate

b. β-adrenergic blocker

c. Calcium channel blocker

d. Angiotensin II receptor blocker

b. β-adrenergic blocker

Rationale
The patient with a history of asthma should avoid β-adrenergic blockers because their side effects include wheezing from bronchospasm. Short-acting nitrates are the first line treatment for a patient with angina and can be used safely in patients. Calcium channel blockers are used in patients if β-blockers are contraindicated, poorly tolerated, or do not control anginal symptoms. Angiotensin II receptor blockers can be given to the patient safely because they have no harmful effects on the respiratory system.

p. 717

The nurse reviews a patient's history and notes an ejection fraction of 30%, diabetes, reports of stabbing chest pain that is relieved upon rest, and prescription for captopril. During a follow-up visit, the primary health care provider finds that the patient is intolerant of captopril. The nurse anticipates that which medication will be prescribed?

a. Valsartan
b. Tirofiban
c. Paclitaxel
d. Carvedilol

a. Valsartan

Rationale
A patient with an ejection fraction of 30%, diabetes mellitus, and angina has a cardiovascular risk. The patient who is intolerant of an angiotensin-converting enzyme (ACE) inhibitor should receive an angiotensin II receptor blocker such as valsartan. Tirofiban is a glycoprotein IIb/IIIa inhibitor that is used to prevent the abrupt closure of the stents during percutaneous coronary intervention (PCI). Paclitaxel prevents the overgrowth of new intima that leads to stent restenosis. Carvedilol is a beta blocker that carries cautions for its use in a patient with diabetes, because it masks the signs of hypoglycemia.

pp. 715-717

The nurse reviews the medication profiles of four patients. The nurse should question a medication that is prescribed for which patient?
Patient :: Med History :: Current Med
A :: Intolerant of catopril :: Losartan
B :: contraindicated to nadol :: Felodipine
C :: receiving felodipine :: isosorbidedinitrate
D :: receiving fluoxetine :: Ranolazine

Patient D

Rationale
Ranolazine is a sodium current inhibitor used to treat chronic angina. It is known to prolong the QT interval as is fluoxetine, so the medication regimen of Patient D needs correction. Patient A is intolerant of angiotensin-converting enzyme (ACE) inhibitors; therefore the patient can take an angiotensin II receptor blocker such as losartan. Patient B has a contraindication to the beta blocker; therefore the patient can take nadolol or can use a calcium channel blocker such as felodipine. For Patient C, a calcium channel blocker, such as felodipine, and a nitrate, such as isosorbide dinitrate, are used in the treatment of Prinzmetal's angina.

pp. 713, 715-717

The nurse is caring for a patient with chronic stable angina that has a history of a stroke. Which prescription should the nurse question?

a. Aspirin

b. Vorapaxar

c. Metoprolol

d. Nitroglycerin

b. Vorapaxar

Rationale
The nurse should be concerned about the prescription for vorapaxar. It must not be used in people who have had a stroke, because the risk for bleeding in the head is too great. Aspirin, nitroglycerin, and metoprolol may be appropriate for treatment of chronic stable angina in a patient who has had a stroke.

p. 715

A patient with angina is prescribed a calcium channel blocker. Upon reviewing the medication history, the nurse finds that the patient is on digoxin. The nurse should monitor the patient for which complication?

a. Prolonging of the QT interval

b. Increase in weight

c. Decrease in blood pressure

d. Increase in serum digoxin levels

d. Increase in serum digoxin levels

Rationale
Calcium channel blockers directly act on cardiac and vascular smooth muscles and promote smooth muscle relaxation and vasodilation of coronary and systemic arteries, thereby increasing the blood flow. The nurse should closely monitor the serum digoxin levels for toxicity because calcium channel blockers potentiate the action of digoxin by increasing serum digoxin levels. QT wave prolongation should be monitored upon administration of sodium current inhibitors. Weight should be monitored in patients taking beta blockers. Long-acting nitrates such as isosorbide dinitrate and isosorbide mononitrate can cause hypotension, resulting in orthostatic hypotension.

A patient with angina asks the nurse about the origin of the pain. The nurse explains that the pain is primarily caused by what condition?

a. Atherosclerosis

b. Myocardial ischemia

c. Movement of a thromboembolus

d. Coronary artery vasoconstriction

b. Myocardial ischemia

Rationale
The pain of angina is caused by an inadequate oxygen supply to the myocardium, resulting in ischemia. The other answer options may lead to myocardial ischemia but are secondary causes.

p. 712

Which type of angina occurs as a result of coronary vasospasm?

a. Nocturnal angina

b. Prinzmetal's angina

c. Microvascular angina

d. Chronic stable angina

b. Prinzmetal's angina

Rationale
Prinzmetal's angina is chest pain that occurs as a result of coronary vasospasm. Nocturnal angina occurs at night, during sleep. Microvascular angina is a result of myocardial ischemia secondary to microvascular disease, affecting the small, distal branches of coronary arteries. Chronic stable angina is the result of myocardial ischemia caused by an oxygen supply/demand mismatch.

Which drug prevents the binding of fibrinogen?

Tirofiban (Aggrastat) It is a reversible antagonist of fibrinogen binding. When administered intravenously, more than 90% of platelet aggregation is inhibited.

Which drug causes vasodilation by preventing conversion of angiotensin?

General Pharmacology. ACE inhibitors produce vasodilation by inhibiting the formation of angiotensin II. This vasoconstrictor is formed by the proteolytic action of renin (released by the kidneys) acting on circulating angiotensinogen to form angiotensin I.

Which drug prevents the binding of fibrinogen to platelets thereby preventing platelet aggregation?

Tirofiban (Aggrastat) Tirofiban is a nonpeptide antagonist of the platelet GP IIb/IIIa receptor; it reversibly prevents vWF, fibrinogen, and other adhesion ligands from binding to the receptor, thus inhibiting platelet aggregation.

Which drugs act by decreasing the contractility of the heart?

Beta‐blockers are one kind of drug which can used for symptomatic relief of angina and prevention of ischaemic events based on the function of reducing myocardial oxygen demand by decreasing heart rate and myocardial contractility.