Show The use of blood collection tubes that contain anticoagulants (EDTA, citrate, and oxalate), which can reduce both the total and ionized calcium concentration. From: Endocrine Biomarkers, 2017 Patients Guide to Cryoglobulinemia Testing Testing for cryo is a very delicate process and not every lab is equipped to do it, just like not every lab technician is familiar with the strictly prescribed protocol of how to properly draw the blood for the test. Here is a guide so you can familiarize yourself with the process and become your best advocate in the lab! Only a correctly done test can lead to correct treatment! Cryoglobulinemia Blood Collection SuppliesBelow text directly from Lee Altenberg’s website Simple Explanation “Cryoglobulin testing involves collecting a blood sample in a prewarmed tube and keeping the sample at or near body temperature during test preparation. The person’s serum is then refrigerated for 72 hours and examined daily for precipitates. If there are any present, then the quantity is estimated and the sample is warmed to determine whether the precipitates dissolve. If they do, then cryoglobulins are present”. https://www.pinnaclehealth.org/wellness-library/blog-and-staywell/health-resources/article/8758 How do I Advocate for Accurate Testing?There re are many psychological, cultural and personal reasons people have a hard time advocating for themselves. You cannot control everything but you can participate in the process to increase your odds for accurate testing. Here are a few tips to help prepare you!
Lee Altenberg, Ph.D. explains CryoCrit.Measuring the Cryocrit in CryoglobulinemiaComments by Lee Altenberg. Revised August 8, 2014 – Quoted directly from Lee Altenberg, Ph.D website.“Because cryoglobulins are thermally unstable, any test that measures the quantity of cryoglobulins in the blood must be performed immediately at the place where the blood is sampled. Tests to measure cryoglobulins can only be sent out to another lab if the lab that drew the blood from the patient immediately separated the serum from the blood cells before sending it out. Otherwise, even if an outside laboratory claims to measure cryoglobulins, any samples sent to it will be invalid because they cannot be processed according to the necessary steps (below). In that case, not only will the quantities of cryoglobulins measured be incorrect, but the test may completely fail to even detect cryoglobulins. Without accurate measurement of cryoglobulin levels, no correct assessment can be made of a patient’s treatments.Therefore, cryoglobulinemia patients must be sure that the lab where their blood is drawn can itself separate the blood cells from the serum at 37°C. Unfortunately, because of the rarity of cryoglobulinemia, most physicians are unaware of the requirements for valid cryoglobulin tests. Fortunately, the Cryocrit test can be performed with the equipment that most any medical testing laboratory has, and should cost only about $20 per test. The only item that may not be immediately available is a 37°C incubator to put the centrifuge inside of. Instead, the centrifuge can be placed in a 37°C walk-in room.” Below are the instructions used by a hospital that treats many cryoglobulinemia patients (the supervisor of the laboratory requested that the identity of the hospital not be divulged, as the questions they have received regarding cryocrit measurements have been burdensome). What is the Basic Checklist for Cryo Blood Collection?BASIC Details for blood collection:
What is the Pre-Checklist before I get my Cryo Testing done?BASIC Pre-Checklist Below is a basic checklist for patients seeking a cryoglobulinemia test.
Why is Advocating for Accurate Cryo Testing so Important?Why self-advocacy is critical in cryoglobulinemia testing?
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