Who is favored Iowa or Oklahoma?

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Oklahoma State is an underdog for the fifth-straight game and second in a row at home inside Boone Pickens Stadium. The Cowboys' season has taken a drastic turn for the worst after a very optimistic start during which they began a perfect 5-0. Since then, the Pokes are 1-3 and left desperately searching for answers.

In preparations this week for Iowa State, Mike Gundy and the rest of his coaching staff had best found solutions to the growing list of issues that Oklahoma State is dealing with, or it could be in store for the program's first three-game losing streak since 2015.

Do not let the Cyclones' record fool you. Iowa State is a bad matchup for the Cowboys. A well-fortified defense and an offense that is starting to find its grove is bad news for Oklahoma State.

The Pokes offense has been out of sorts in recent weeks and the quarterback position is still unpredictable with fourth-year starter Spencer Sanders dealing with injury. Oklahoma State sent in redshirt freshman Gunnar Gundy, son of head coach Gundy, as a reserve late in a shutout loss at Kansas State on Oct. 29 and started true freshman Garret Rangel at Kansas last week.

There is a chance for either one of the three to start against Iowa State.

The Cowboys' defense is struggling and is now giving up more than 31 points per game — the most since 2018. The Cyclones' offense may be one of the least efficient units in the Big 12, but their confidence is high after scoring three touchdowns in the fourth quarter against West Virginia last week.

Unless Oklahoma State can find a way to turn things around, this has the feeling of another rough week and frustrating result.

Oklahoma State leads the all-time series with a 33-20-3 (.616) record, including a 18-7-2 (.704) advantage in games played in Stillwater. The Cowboys have won 10 of the past 13 matchups, including six of the past seven played at Boone Pickens Stadium.

Coach Gundy is 10-4 (.714) in his career against Iowa State, while Cyclones head coach Matt Campbell is 2-4 (.333) against Oklahoma State.

GOPOKES247.COM PICKS

SPREAD: Iowa State -1.5
MONEY LINE: Iowa State -125
TOTAL: Under 48.5
SCORE PREDICTION: Iowa State 27, Oklahoma State 20

GoPokes247.com Record in 2022: 14-10-0

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2022 OKLAHOMA STATE BETTING RESULTS

  • SU: 6-3
  • ATS: 5-4
  • O/U: 6-3
  • ATS-Home: 3-2
  • ATS-Road: 2-2
  • ATS-Favorite: 2-2
  • ATS-Underdog: 3-2

2022 IOWA STATE BETTING RESULTS

  • SU: 4-5
  • ATS: 5-4
  • O/U: 2-7
  • ATS-Home: 4-3
  • ATS-Road: 2-1
  • ATS-Favorite: 2-3
  • ATS-Underdog: 3-1

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Week 9's Saturday action kicks off with a Big 12 matchup between the Oklahoma Sooners and Iowa State Cyclones.

Oklahoma snapped a three-game losing streak by defeating No. 19 Kansas, while Iowa State is trying to shake a four-game losing streak.

Can the Cyclones snap their losing skid? Find out in our free best college football picks and predictions for Oklahoma vs. Iowa State below. 

Oklahoma vs Iowa State best odds

Oklahoma vs Iowa State picks and predictions

Iowa State is a short home underdog but I think they're the best play in this contest. 

The Cyclones' defense is the best part of this team, allowing the sixth-fewest points in the country and an eighth-best 284 total yards of offense per contest.

Iowa State doesn’t have the sexy individual defensive numbers, but they play exceptionally well as a unit. They boast four players with over 34 tackles each, and opposing offenses have difficulty running the football.

Passing isn’t any easier, as the Cyclones allow a 32nd-best 11.63 passing yards per play. The Sooners' offense moves the football and hasn’t scored less than 31 points in any game when junior QB Dillon Gabriel plays all four quarters.

The junior signal-caller threw for 403 yards with a pair of TDs and his first interception of the year in last week's win over No. 19 Kansas. Wideout Marvin Mimms and tight end Brayden Willis have combined for 854 yards with eight TDs with Eric Gray adding 695 yards and five scores on the ground.

The Cyclones should get enough stops, but it will be up to the Iowa State offense and sophomore QB Hunter Dekkers to get the job done on Saturday.

Dekkers is coming off the best game of his career, throwing for 329 yards with a pair of TDs alongside his seventh miscue of the season in ISU's last game — a loss — to No. 22 Texas. With wideouts Xavier Hutchinson and Jaylin Noel, he has great receiving options in a steadily improving offense. They'll have an excellent opportunity against a defense they can beat.

The Sooners' defense is their Achilles heel. They’ve allowed a 108th-best 442 yards of offense and surrendered at least 42 points in their past four contests. Oklahoma has a decent pass rush and has picked off six balls, but they can’t keep opponents out of the end zone.

Iowa State has lost to three Top-25 teams by a combined total of 11 points and has an excellent opportunity Saturday, but it all begins with the defense. The Cyclones might allow teams to move the ball but is stingy in points allowed, and if they can keep the Sooners and Gabriel from going off early, they’ll give their offense a chance to win this game.

The Cyclones' offense is steadily improving and probably facing the worst defensive Big 12 unit they’ve seen. The Cyclones' scoring inabilities have cost them games, but they are playing at home against a soft defense they can score multiple TDs against with a defense that can slow the Sooners down just enough to outscore them. I’m going with Iowa State to win outright. 

My best bet: Iowa State moneyline (+105 at FanDuel)

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Oklahoma vs Iowa State spread analysis

I like the moneyline the most in this game, but I'd also consider Iowa State +1.5 as my best bet. Here are some additional notes to keep in mind. 

Oklahoma brings its No. 15-ranked rushing offense vs. Iowa State's 17th-ranked rushing defense. 

Oklahoma RBs have carried the ball a nation-best 54 times in close and late situations they face — while Iowa State has 19 passing first downs during those same circumstances.

The Sooners average 3.1 TD/FGs red-zone scores per contest — the Cyclones are 10th with 2.1 TD/FGs allowed. Oklahoma allows an 81st-best 3.2 red zone TD/FGs 2.7 TD/FGs per red zone visit.

The Sooners are 2-5 against the spread in their last seven meetings.

Covers college football betting analysis

Oklahoma vs Iowa State Over/Under analysis

The number has opened at 55 but has settled at 56 points — and I’m leaning towards the Over.

It would take a Herculean effort for the Cyclones to limit the Sooners to 15.1 points. It's possible, considering how they’ve limited Kansas, Kansas State, and Texas to a combined 48 points, but it isn’t likely. Oklahoma has a big-time offense, and this contest could quickly end up in a shootout.

As previously mentioned, the Sooners' defense isn’t very good, while the Cyclones' offense has steadily improved. Oklahoma allows a 326.0 red zone passer rating, the worst mark in all of college football. Dekker is completing 69% of his passing attempts this season, and he could do serious damage to Oklahoma. 

Oklahoma averages 14.0 second-half points per contest, facing an Iowa State defense allowing 5.7. Meanwhile, the Sooners allow 11.9 points in the second half facing a Cyclones offense scoring 8.3 points in the bottom half of the game. 

The Over is 8-3 over their last 11 meetings and 4-2 over their previous six matchups. 

Oklahoma vs Iowa State betting trend to know

The underdog is 5-2 ATS in their last seven meetings. Find more NCAA betting trends for Oklahoma vs. Iowa State.

Who is favored in the Iowa State Oklahoma game?

Oklahoma: Oklahoma vs. Iowa State spread: Oklahoma -1.5.

Who is favored to win Oklahoma vs Oklahoma?

Oklahoma State: Oklahoma vs. Oklahoma State spread: Oklahoma -7.5.

Who is favored OSU or OU?

Oklahoma State vs Oklahoma Odds.

Who is favored in the OU West Virginia game?

West Virginia vs. Oklahoma spread: Oklahoma -8.